serum level of vascular cell adhesion molecule-1 (svcam-1) in sera

Authors

mehdi farzadnia department of pathology, school of medicine, mashhad university of medical sciences, mashhad, iran.

hossein ayatollahi department of hematopathology and blood banking; school of medicine, mashhad university of medical sciences, mashhad, iran.

maliheh hasan zade department of obstetrics and gynecology, school of medicine, mashhad university of medical sciences, mashhad, iran.

mohammad hadi sadeghian department of hematopathology and blood banking; school of medicine, mashhad university of medical sciences, mashhad, iran.

abstract

endothelial dysfunction is thought to be a central pathogenic feature in preeclampsia on the basis of elevated adhesion molecules. soluble forms of these molecules can be detected in plasma, and their concentrations are thought to reflect the degree of activation of a particular cell type. the aim of the present study was to compare the levels of soluble vascular cell adhesion molecule-1 (svcam-1) in sera of normal and preeclamptic pregnancies. a cross-sectional study was conducted to determine the plasma concentrations of svcam-1 in peripheral blood obtained from normal pregnant women (n=40), mild preeclampsia (n=37) and severe preeclampsia (n=38). concentrations of soluble adhesion molecule was determined with enzyme-linked immunosorbant assay (elisa). serum concentration of svcam-1 was significantly higher in severe preeclampsia (p

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Journal title:
acta medica iranica

جلد ۴۷، شماره ۱، صفحات ۶۵-۷۰

Keywords
[ ' p r e ' , ' e c l a m p s i a ' , ' c e l l a d h e s i o n m o l e c u l e s ' , ' v a s u r l a r c e l l a d h e s i o n m o l e c u l e ' , 1 , ' v c a m ' , 1 ]

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